Press "Enter" to skip to content

What factors influence the binding of oxygen to myoglobin?

The binding of oxygen to hemoglobin is not as simple as that for myoglobin. Several factors influence oxygen binding to hemoglobin, including the partial pressure of oxygen itself, pH, the concentration of CO2, and 2,3-bisphosphoglycerate (BPG).

Does myoglobin have a prosthetic group?

Myoglobin is a single-chain globular protein with the heme prosthetic group in the center.

Which structural feature of myoglobin is the binding site for oxygen?

These binding sites are called the fifth and sixth coordination sites. In myoglobin, the fifth coordination site is occupied by the imidazole ring from a histidine residue on the protein. This hisitidine is referred to as the proximal histidine. The sixth coordination site is available to bind oxygen.

What causes increased myoglobin?

Increased myoglobin levels can occur after muscle injections or strenuous exercise. Because the kidneys remove myoglobin from the blood, the myoglobin level may be high in people whose kidneys are failing. Heavy alcohol consumption and certain drugs can also cause muscle injury and increase myoglobin in the blood.

How do you treat high myoglobin?

If your myoglobin level rises too high, you may have to get IV (intravenous) fluids or other treatments to help flush the extra myoglobin out of your body.

How can you tell the difference between hematuria and hemoglobinuria?

If freshly collected urine from a patient with hematuria is centrifuged, red blood cells settle at the bottom of the tube, leaving a clear yellow urine supernatant. If the red color is due to hemoglobinuria, the urine sample remains clear red after centrifugation.

How is hemoglobinuria diagnosed?

Hemoglobinuria test is a urine test that checks for hemoglobin in the urine. A clean-catch urine sample is performed by collecting the sample of urine in midstream.

Why is there hemoglobin in my urine?

If the red blood cells break down in the blood vessels, their parts move freely in the bloodstream. If the level of hemoglobin in the blood rises too high, then hemoglobin begins to appear in the urine. This is called hemoglobinuria.

What does blood in the urine indicate?

Most causes of blood in your urine are not serious, But sometimes red or white blood cells in your urine can mean that you have a medical condition that needs treatment, such as a kidney disease, urinary tract infection, or liver disease.