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What creates phosphodiester bonds between DNA fragments?

This strand is known as the lagging strand. Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase, which creates phosphodiester bonds between the 3′-OH of one end and the 5′ phosphate of the other strand.

Where does a phosphodiester bond is formed?

A phosphodiester bond occurs when two of the hydroxyl groups in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds. Phosphodiester bonds are central to all life on Earth,[fn 1] as they make up the backbone of the strands of nucleic acid.

What type of bond is formed between nucleotides during polymerization of DNA by DNA polymerase?

hydrogen bonds

What catalyzes the formation of phosphodiester bonds between a DNA strand and a new nucleotide being added during DNA replication?

C – DNA polymerase catalyzes the formation of a phosphodiester bond between the 5′ phosphate of one nucleotide and the 3′ hydroxyl on the incoming nucleotide; therefore, chain growth is said to occur in the 5′ arrow 3′ direction. DNA polymerases are enzymes that copy: A. DNA into DNA.

What enzyme breaks Phosphodiester?


What enzyme removes the RNA primers?

RNase H

What does Phosphodiester mean?

: an oligonucleotide with an oxygen atom linking consecutive nucleotides — see phosphodiester bond — compare phosphorothioate.

What bonds are formed in DNA replication?

The DNA double helix has two types of bonds, covalent and hydrogen. Covalent bonds exist within each linear strand and strongly bond bases, sugars, and phosphate groups (both within each component and between components).

Who are the major players in DNA replication?

Terms in this set (5)

  • DNA polymerase III. leading and lagging strand synthesis.
  • Ligase. seals the nick in the phosphodiester bond between two Okazaki fragments.
  • Helicase. breaking the hydrogen bond between nitrogenous bases, generating single stranded DNA templates.
  • Topoisomerase.
  • Primase.

What is the last step in DNA replication?

5) The last step of DNA Replication is the Termination. This process happens when the DNA Polymerase reaches to an end of the strands.