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What are the causes of non linear pharmacokinetics?

Causes of Nonlinearity 1. Drug Absorption Three causes: I) Solubility / dissolution of drug is rate-limited; Griseofulvin – at high concentration in intestine. II) Carrier – mediated transport system; Ascorbic acid – saturation of transport system.

Which are the causes of non linearity?

Causes of non-linearity Non-linearity may occur by one of the following factors namely drug absorption, distribution, metabolism and excretion.

What are the limitations of one compartment model?

DISADVANTAGES • Drug given by IV route may behave according to single compartment model but the same drug given by oral route may show 2 compartment behaviour. The type of compartment behaviour i.E. Type of compartment model may change with the route of administration.

Which creates non linearity in drug distribution and not in drug absorption?

If any changes occur in these constants, this indicates nonlinearity. 2. Which of the following creates nonlinearity in drug distribution and not in drug absorption? Nonlinearity in drug distribution occurs when saturation of binding sites on plasma proteins or saturation of tissue binding sites.

Which drug is not modeled by non linear pharmacokinetics?

Some examples of drugs which exhibit non-linear kinetic behaviour are phenytoin, ethanol, salicylate and, in some individuals, theophylline. Phenytoin: Phenytoin exhibits marked saturation of metabolism at concentrations in the therapeutic range (10-20 mg/L) (Fig. 2).

What does it mean if a drug is saturable?

Drug absorption is the process by which a drug molecule moves from the site of administration to the systemic circulation. Following intravenous administration, there is no absorption process since the drug is directly introduced into the blood stream. This is called saturable drug absorption.

What is the difference between zero order and first order decay?

The fundamental difference between zero and first-order kinetics is their elimination rate compared to total plasma concentration. Zero-order kinetics undergo constant elimination regardless of the plasma concentration, following a linear elimination phase as the system becomes saturated.

What is half-life period of reaction?

The half-life of a reaction (t1/2), is the amount of time needed for a reactant concentration to decrease by half compared to its initial concentration. Its application is used in chemistry and medicine to predict the concentration of a substance over time.

What is meant by half life period?

Half-life, in radioactivity, the interval of time required for one-half of the atomic nuclei of a radioactive sample to decay (change spontaneously into other nuclear species by emitting particles and energy), or, equivalently, the time interval required for the number of disintegrations per second of a radioactive …

What is considered a short half life?

Half-lives of drugs are therefore generalizations and not exact. Shorter half-life drugs tend to take action quickly, and their effects may wear off rapidly as well. A long half-life drug, on the other hand, may stay in the body for longer than a person wants it to as the effects can be prolonged.